Version 5.4
Homo sapiens Protein: UGT2B28
Summary
InnateDB Protein IDBP-480675.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGT2B28
Protein Name UDP glucuronosyltransferase 2 family, polypeptide B28
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000427399
InnateDB Gene IDBG-21770 (UGT2B28)
Protein Structure
UniProt Annotation
Function UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active. {ECO:0000269PubMed:11300766}.
Subcellular Localization Microsome membrane {ECO:0000269PubMed:11300766}; Single-pass membrane protein {ECO:0000269PubMed:11300766}. Endoplasmic reticulum membrane {ECO:0000269PubMed:11300766}; Single-pass membrane protein {ECO:0000269PubMed:11300766}.
Disease Associations
Tissue Specificity Expressed in the liver, breast and kidney. {ECO:0000269PubMed:11300766}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015020 glucuronosyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase
PFAM PF00201
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BY64
PhosphoSite PhosphoSite-Q9BY64
TrEMBL
UniProt Splice Variant
Entrez Gene 54490
UniGene Hs.653154
RefSeq NP_001193933
HUGO HGNC:13479
OMIM 606497
CCDS CCDS56330
HPRD 05931
IMGT
EMBL AB451456 AF177272 AF177273 AF177274
GenPept AAK31807 AAK31808 AAK31809 BAG70270

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca