Version 5.4
Homo sapiens Gene: UGT1A9
Summary
InnateDB Gene IDBG-409446.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGT1A9
Gene Name UDP glucuronosyltransferase 1 family, polypeptide A9
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000241119
Encoded Proteins
IDBP-83544
UDP glucuronosyltransferase 1 family, polypeptide A9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:233671853-233773300
Strand Forward strand
Band q37.1
Transcripts
ENST00000354728 ENSP00000346768
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0004857 enzyme inhibitor activity
GO:0015020 glucuronosyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0019899 enzyme binding
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0017144 drug metabolic process
GO:0030259 lipid glycosylation
GO:0042573 retinoic acid metabolic process
GO:0043086 negative regulation of catalytic activity
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045922 negative regulation of fatty acid metabolic process
GO:0051552 flavone metabolic process
GO:0052695 cellular glucuronidation
GO:0052696 flavonoid glucuronidation
GO:0052697 xenobiotic glucuronidation
GO:2001030 negative regulation of cellular glucuronidation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_6784
Glucuronidation pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00830
Retinol metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00500
Starch and sucrose metabolism pathway
hsa00140
Steroid hormone biosynthesis pathway
hsa00053
Ascorbate and aldarate metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00860
Porphyrin and chlorophyll metabolism pathway
hsa00982
Drug metabolism pathway
hsa00983
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt O60656
TrEMBL A9UKF4 Q53E75 Q5DSZ5
UniProt Splice Variant
Entrez Gene 54600
UniGene Hs.643992
RefSeq NM_021027
HUGO HGNC:12541
OMIM 191740 606434
CCDS CCDS2505
HPRD
IMGT
EMBL AC006985 AC019072 AF056188 AF297091 AF297093 AK313510 AY273792 AY282534 AY282535 AY282536 AY282537 AY282538 AY282539 AY282540 AY282541 AY282542 AY326393 AY326394 AY326395 AY395515 AY435144 AY635191 AY635192 AY635193 AY635194 AY751504 AY751507 AY751508 AY751513 AY751515 AY751516 BC058844 CH471063 DQ068746 DQ068747 DQ364246 S55985
GenPept AAB19791 AAC31425 AAG29816 AAG30418 AAH58844 AAQ84220 AAQ84221 AAQ84222 AAQ84223 AAQ84224 AAQ84225 AAQ84226 AAQ84227 AAQ84228 AAQ84229 AAQ92914 AAQ92915 AAQ92916 AAR86934 AAR95645 AAT77229 AAT77230 AAT77231 AAT77232 AAY32605 AAY32606 AAY32607 AAY32609 AAY32610 AAY32611 AAY56382 AAY56383 ABC96770 BAG36290 EAW71054
RNA Seq Atlas 54600

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca