InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UGT1A9

Summary

InnateDB Protein

IDBP-83544.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGT1A9

Protein Name

UDP glucuronosyltransferase 1 family, polypeptide A9

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346768

InnateDB Gene

IDBG-409446 (UGT1A9)

Protein Structure

UniProt Annotation

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269PubMed:19545173}.

Subcellular Localization

Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Liver. Isoform 1 and isoform 2 are expressed in liver, kidney, colon, esophagus and small intestine. {ECO:0000269PubMed:18004212}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0004857	enzyme inhibitor activity
GO:0015020	glucuronosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0019899	enzyme binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0017144	drug metabolic process
GO:0030259	lipid glycosylation
GO:0042573	retinoic acid metabolic process
GO:0043086	negative regulation of catalytic activity
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045922	negative regulation of fatty acid metabolic process
GO:0051552	flavone metabolic process
GO:0052695	cellular glucuronidation
GO:0052696	flavonoid glucuronidation
GO:0052697	xenobiotic glucuronidation
GO:2001030	negative regulation of cellular glucuronidation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome