Version 5.4
Homo sapiens Gene: ITGB5
Summary
InnateDB Gene IDBG-53924.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGB5
Gene Name integrin, beta 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000082781
Encoded Proteins
IDBP-53926
integrin, beta 5
IDBP-480526
integrin, beta 5
IDBP-810906
integrin, beta 5
IDBP-483830
integrin, beta 5
IDBP-484137
integrin, beta 5
IDBP-474704
integrin, beta 5
IDBP-810908
integrin, beta 5
IDBP-810910
integrin, beta 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:124761948-124901418
Strand Reverse strand
Band q21.2
Transcripts
ENST00000296181 ENSP00000296181
ENST00000460797
ENST00000461306
ENST00000481591 ENSP00000420814
ENST00000488466 ENSP00000477446
ENST00000474838
ENST00000496703 ENSP00000418367
ENST00000476988
ENST00000465464 ENSP00000418079
ENST00000483168 ENSP00000419198
ENST00000608657 ENSP00000477230
ENST00000608107 ENSP00000476655
ENST00000608945
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005178 integrin binding
GO:0005515 protein binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006936 muscle contraction
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
GO:0030198 extracellular matrix organization
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087 innate immune response
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0016020 membrane
GO:0031252 cell leading edge
GO:0043235 receptor complex
GO:0045335 phagocytic vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022817
View Gene Order
ENSBTAG00000013755
Not yet available
Pathways
NETPATH
NetPath_22
Leptin pathway
REACTOME
REACT_111174
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_20558
Smooth Muscle Contraction pathway
REACT_118779
Extracellular matrix organization pathway
REACT_163942
Syndecan interactions pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_17044
Muscle contraction pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
hsa04145
Phagosome pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin_cs_pathway
Integrin family cell surface interactions
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002213
HUGO
OMIM
CCDS CCDS3030
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca