InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGB5

Summary

InnateDB Protein

IDBP-53926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB5

Protein Name

integrin, beta 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296181

InnateDB Gene

IDBG-53924 (ITGB5)

Protein Structure

UniProt Annotation

Function

Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006936	muscle contraction
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0030198	extracellular matrix organization
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087	innate immune response

Cellular Component

GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0016020	membrane
GO:0031252	cell leading edge
GO:0043235	receptor complex
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR014836 Integrin beta subunit, cytoplasmic domain
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold

PFAM

PF00092
PF00362
PF07965
PF07974
PF08725

PRINTS

PR01186

PIRSF

PIRSF002512

SMART

SM00327
SM00187
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References