Version 5.4
Homo sapiens Gene: MGLL
Summary
InnateDB Gene IDBG-55027.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGLL
Gene Name monoglyceride lipase
Synonyms HU-K5; HUK5; MAGL; MGL
Species Homo sapiens
Ensembl Gene ENSG00000074416
Encoded Proteins
IDBP-55029
monoglyceride lipase
IDBP-233858
monoglyceride lipase
IDBP-233862
monoglyceride lipase
IDBP-383574
monoglyceride lipase
IDBP-383575
monoglyceride lipase
IDBP-475402
monoglyceride lipase
IDBP-484038
monoglyceride lipase
IDBP-482702
monoglyceride lipase
IDBP-484737
monoglyceride lipase
IDBP-484945
monoglyceride lipase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:127689062-127823250
Strand Reverse strand
Band q21.3
Transcripts
ENST00000265052 ENSP00000265052
ENST00000398104 ENSP00000381176
ENST00000398101 ENSP00000381173
ENST00000434178 ENSP00000402798
ENST00000453507 ENSP00000404146
ENST00000496306 ENSP00000417060
ENST00000476682
ENST00000487473 ENSP00000420125
ENST00000484451 ENSP00000419340
ENST00000465597
ENST00000479967
ENST00000493611 ENSP00000417689
ENST00000476654
ENST00000494830 ENSP00000417489
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004622 lysophospholipase activity
GO:0008289 lipid binding
GO:0016787 hydrolase activity
GO:0042803 protein homodimerization activity
GO:0047372 acylglycerol lipase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006644 phospholipid metabolic process
GO:0006954 inflammatory response
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0009966 regulation of signal transduction
GO:0019369 arachidonic acid metabolic process
GO:0019433 triglyceride catabolic process
GO:0030168 platelet activation
GO:0036155 acylglycerol acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0046464 acylglycerol catabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0050727 regulation of inflammatory response
GO:0051930 regulation of sensory perception of pain
GO:0060292 long term synaptic depression
GO:2000124 regulation of endocannabinoid signaling pathway
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033174
View Gene Order
ENSBTAG00000018248
Not yet available
Pathways
NETPATH
REACTOME
REACT_19308
Arachidonate production from DAG pathway
REACT_2202
Effects of PIP2 hydrolysis pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_121122
Acyl chain remodeling of DAG and TAG pathway
REACT_494
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_14797
Signaling by GPCR pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q99685
TrEMBL C9J8Q3 C9JAM4
UniProt Splice Variant
Entrez Gene 11343
UniGene Hs.277035 Hs.641697
RefSeq NM_001003794 XM_005247093 NM_001256585 NM_007283
HUGO HGNC:17038
OMIM 609699
CCDS CCDS43148 CCDS46902 CCDS58852
HPRD 17574
IMGT
EMBL AC023593 AC117480 AJ270950 AK091314 AK304844 AK315529 BC000551 BC006230 BX640777 CH471052 CR456835 U67963
GenPept AAB39616 AAH00551 AAH06230 BAG37910 BAG52334 BAH14267 CAC43316 CAE45873 CAG33116 EAW79330 EAW79331
RNA Seq Atlas 11343

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca