InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MGLL

Summary

InnateDB Protein

IDBP-55029.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGLL

Protein Name

monoglyceride lipase

Synonyms

HU-K5; HUK5; MAGL; MGL;

Species

Homo sapiens

Ensembl Protein

ENSP00000265052

InnateDB Gene

IDBG-55027 (MGLL)

Protein Structure

UniProt Annotation

Function

Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. {ECO:0000250, ECO:0000269PubMed:20079333}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in adipose tissue, lung, liver, kidney, brain and heart. {ECO:0000269PubMed:11470505}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004622	lysophospholipase activity
GO:0008289	lipid binding
GO:0016787	hydrolase activity
GO:0042803	protein homodimerization activity
GO:0047372	acylglycerol lipase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006644	phospholipid metabolic process
GO:0006954	inflammatory response
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0009966	regulation of signal transduction
GO:0019369	arachidonic acid metabolic process
GO:0019433	triglyceride catabolic process
GO:0030168	platelet activation
GO:0036155	acylglycerol acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0046464	acylglycerol catabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0050727	regulation of inflammatory response
GO:0051930	regulation of sensory perception of pain
GO:0060292	long term synaptic depression
GO:2000124	regulation of endocannabinoid signaling pathway

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000073 Alpha/beta hydrolase fold-1
IPR000801 Putative esterase
IPR002921 Fungal lipase-like domain
IPR013094 Alpha/beta hydrolase fold-3
IPR022742 Putative lysophospholipase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00561
PF00756
PF01764
PF07859
PF12146

PRINTS

PR00111

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99685