Version 5.4
Bos taurus Gene: BT.41700
Summary
InnateDB Gene IDBG-630483.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.41700
Gene Name Ubiquitin carboxyl-terminal hydrolase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019314
Encoded Proteins
IDBP-682015
Ubiquitin carboxyl-terminal hydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26305951
[Mus musculus] Usp25 physically associates with Traf3 and Traf6 after infection by RNA or DNA viruses and promotes innate antiviral responses by protecting virus-induced proteasome-dependent or independent degradation of Traf3 and Traf6.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155313:
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:20664990-20798853
Strand Reverse strand
Band
Transcripts
ENSBTAT00000025716 ENSBTAP00000025716
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0032183 SUMO binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000155313
View Gene Order
ENSMUSG00000022867
View Gene Order
Cross-References
SwissProt
TrEMBL F1MP13
UniProt Splice Variant
Entrez Gene 524531
UniGene
RefSeq XM_002684646 XM_602857
HUGO HGNC:12624
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02000497
GenPept
RNA Seq Atlas 524531

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca