InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EZH2

Summary

InnateDB Gene

IDBG-637180.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EZH2

Gene Name

histone-lysine N-methyltransferase EZH2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009426

Encoded Proteins

IDBP-689179

enhancer of zeste homolog 2 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26668377

[Mus musculus] Selective loss of the histone-lysine N-methyltransferase Ezh2 or inhibition of its enzymatic activity increases generation of the Il2rb (CD122) natural killer (NK) precursors and mature NK progeny.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106462:
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:112815327-112848415

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000012405

ENSBTAP00000012405

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 177 interaction(s) predicted by orthology.

Predicted by orthology
Total	177 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0031490	chromatin DNA binding
GO:0042054	histone methyltransferase activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001932	regulation of protein phosphorylation
GO:0006306	DNA methylation
GO:0010468	regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0014013	regulation of gliogenesis
GO:0016571	histone methylation
GO:0021695	cerebellar cortex development
GO:0032320	positive regulation of Ras GTPase activity
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter
GO:0042127	regulation of cell proliferation
GO:0043406	positive regulation of MAP kinase activity
GO:0045605	negative regulation of epidermal cell differentiation
GO:0045814	negative regulation of gene expression, epigenetic
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0050767	regulation of neurogenesis
GO:0051154	negative regulation of striated muscle cell differentiation
GO:0070301	cellular response to hydrogen peroxide
GO:0070314	G1 to G0 transition
GO:0070734	histone H3-K27 methylation
GO:0071168	protein localization to chromatin
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle