InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EZH2

Summary

InnateDB Protein

IDBP-689179.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EZH2

Protein Name

enhancer of zeste homolog 2 (Drosophila)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000012405

InnateDB Gene

IDBG-637180 (EZH2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 177 interaction(s) predicted by orthology.

Predicted by orthology
Total	177 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0031490	chromatin DNA binding
GO:0042054	histone methyltransferase activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001932	regulation of protein phosphorylation
GO:0006306	DNA methylation
GO:0010468	regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0014013	regulation of gliogenesis
GO:0016571	histone methylation
GO:0021695	cerebellar cortex development
GO:0032320	positive regulation of Ras GTPase activity
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter
GO:0042127	regulation of cell proliferation
GO:0043406	positive regulation of MAP kinase activity
GO:0045605	negative regulation of epidermal cell differentiation
GO:0045814	negative regulation of gene expression, epigenetic
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0050767	regulation of neurogenesis
GO:0051154	negative regulation of striated muscle cell differentiation
GO:0070301	cellular response to hydrogen peroxide
GO:0070314	G1 to G0 transition
GO:0070734	histone H3-K27 methylation
GO:0071168	protein localization to chromatin
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0035098	ESC/E(Z) complex
GO:0045120	pronucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001005 SANT/Myb domain
IPR001214 SET domain
IPR009057 Homeodomain-like
IPR021654 WD repeat binding protein EZH2
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF00249
PF00856
PF11616

PRINTS

PIRSF

SMART

SM00717
SM00317

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite