InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BUB1

Summary

InnateDB Gene

IDBG-65670.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BUB1

Gene Name

budding uninhibited by benzimidazoles 1 homolog (yeast)

Synonyms

BUB1A; BUB1L; hBUB1

Species

Homo sapiens

Ensembl Gene

ENSG00000169679

Encoded Proteins

IDBP-65672

budding uninhibited by benzimidazoles 1 homolog (yeast)

IDBP-294864

budding uninhibited by benzimidazoles 1 homolog (yeast)

IDBP-384579

budding uninhibited by benzimidazoles 1 homolog (yeast)

IDBP-384581

budding uninhibited by benzimidazoles 1 homolog (yeast)

IDBP-384582

budding uninhibited by benzimidazoles 1 homolog (yeast)

IDBP-593804

budding uninhibited by benzimidazoles 1 homolog (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer. [provided by RefSeq, Jul 2008]
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:110637698-110678114

Strand

Reverse strand

Band

q13

Transcripts

ENST00000302759	ENSP00000302530
ENST00000409311	ENSP00000386701
ENST00000447014	ENSP00000402883
ENST00000420328	ENSP00000409713
ENST00000436916	ENSP00000392219
ENST00000478175
ENST00000466333
ENST00000490632
ENST00000465029
ENST00000477481
ENST00000468927
ENST00000535254	ENSP00000441013

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007059	chromosome segregation
GO:0007063	regulation of sister chromatid cohesion
GO:0007067	mitotic nuclear division
GO:0007093	mitotic cell cycle checkpoint
GO:0007094	mitotic spindle assembly checkpoint
GO:0008283	cell proliferation
GO:0016032	viral process
GO:0051983	regulation of chromosome segregation
GO:0071173	spindle assembly checkpoint
GO:0071174	mitotic spindle checkpoint
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane