InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BUB1

Summary

InnateDB Protein

IDBP-294864.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BUB1

Protein Name

budding uninhibited by benzimidazoles 1 homolog (yeast)

Synonyms

BUB1A; BUB1L; hBUB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000386701

InnateDB Gene

IDBG-65670 (BUB1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007063	regulation of sister chromatid cohesion
GO:0007067	mitotic nuclear division
GO:0007093	mitotic cell cycle checkpoint
GO:0007094	mitotic spindle assembly checkpoint
GO:0016032	viral process
GO:0051983	regulation of chromosome segregation
GO:0071173	spindle assembly checkpoint

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR013212 Mad3/BUB1 homology region 1

PFAM

PF08311

PRINTS

PIRSF

SMART

SM00220
SM00777

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43683