Version 5.4
Homo sapiens Gene: PCSK5
Summary
InnateDB Gene IDBG-71797.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCSK5
Gene Name proprotein convertase subtilisin/kexin type 5
Synonyms PC5; PC6; PC6A; SPC6
Species Homo sapiens
Ensembl Gene ENSG00000099139
Encoded Proteins
IDBP-71799
proprotein convertase subtilisin/kexin type 5
IDBP-71803
proprotein convertase subtilisin/kexin type 5
IDBP-373257
proprotein convertase subtilisin/kexin type 5
IDBP-373263
proprotein convertase subtilisin/kexin type 5
IDBP-585627
proprotein convertase subtilisin/kexin type 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:75890644-76362339
Strand Forward strand
Band q21.13
Transcripts
ENST00000376767 ENSP00000365958
ENST00000376752 ENSP00000365943
ENST00000424854 ENSP00000411654
ENST00000455778 ENSP00000407239
ENST00000545128 ENSP00000446280
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0042277 peptide binding
Biological Process
GO:0001822 kidney development
GO:0002001 renin secretion into blood stream
GO:0006465 signal peptide processing
GO:0006508 proteolysis
GO:0007267 cell-cell signaling
GO:0007507 heart development
GO:0007566 embryo implantation
GO:0009952 anterior/posterior pattern specification
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0019058 viral life cycle
GO:0030323 respiratory tube development
GO:0032455 nerve growth factor processing
GO:0035108 limb morphogenesis
GO:0042089 cytokine biosynthetic process
GO:0043043 peptide biosynthetic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048566 embryonic digestive tract development
GO:0048706 embryonic skeletal system development
Cellular Component
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0005796 Golgi lumen
GO:0016021 integral component of membrane
GO:0030141 secretory granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024713
View Gene Order
ENSBTAG00000008101
Not yet available
Pathways
NETPATH
REACTOME
REACT_11062
NGF processing pathway
REACT_11061
Signalling by NGF pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368542 Hs.603796 Hs.617867 Hs.732073
RefSeq NM_001190482 NM_006200 XM_005252039
HUGO
OMIM
CCDS CCDS55320 CCDS6652
HPRD 08985
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca