InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PCSK5

Summary

InnateDB Protein

IDBP-71803.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCSK5

Protein Name

proprotein convertase subtilisin/kexin type 5

Synonyms

PC5; PC6; PC6A; SPC6;

Species

Homo sapiens

Ensembl Protein

ENSP00000365943

InnateDB Gene

IDBG-71797 (PCSK5)

Protein Structure

UniProt Annotation

Function

Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins. {ECO:0000269PubMed:19764806, ECO:0000269PubMed:20555025, ECO:0000269PubMed:22740495}.

Subcellular Localization

Isoform PC6A: Secreted. Note=Secreted through the regulated secretory pathway. {ECO:0000250}.Isoform PC6B: Endomembrane system; Single- pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in T-lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0008233	peptidase activity
GO:0042277	peptide binding

Biological Process

GO:0001822	kidney development
GO:0002001	renin secretion into blood stream
GO:0006465	signal peptide processing
GO:0006508	proteolysis
GO:0007267	cell-cell signaling
GO:0007507	heart development
GO:0007566	embryo implantation
GO:0009952	anterior/posterior pattern specification
GO:0016485	protein processing
GO:0016486	peptide hormone processing
GO:0019058	viral life cycle
GO:0030323	respiratory tube development
GO:0032455	nerve growth factor processing
GO:0035108	limb morphogenesis
GO:0042089	cytokine biosynthetic process
GO:0043043	peptide biosynthetic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048566	embryonic digestive tract development
GO:0048706	embryonic skeletal system development

Cellular Component

GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0005796	Golgi lumen
GO:0016021	integral component of membrane
GO:0030141	secretory granule

Protein Structure and Domains

PDB ID

InterPro

IPR000209 Peptidase S8/S53 domain
IPR002884 Proprotein convertase, P
IPR006212 Furin-like repeat
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR010909 PLAC
IPR015500 Peptidase S8, subtilisin-related

PFAM

PF00082
PF01483
PF08686

PRINTS

PR00723

PIRSF

SMART

SM00261

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt