Version 5.4
Homo sapiens Gene: PRKRA
Summary
InnateDB Gene IDBG-76030.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKRA
Gene Name protein kinase, interferon-inducible double stranded RNA dependent activator
Synonyms DYT16; PACT; RAX
Species Homo sapiens
Ensembl Gene ENSG00000180228
Encoded Proteins
IDBP-76032
protein kinase, interferon-inducible double stranded RNA dependent activator
IDBP-387793
protein kinase, interferon-inducible double stranded RNA dependent activator
IDBP-387795
protein kinase, interferon-inducible double stranded RNA dependent activator
IDBP-387797
protein kinase, interferon-inducible double stranded RNA dependent activator
IDBP-387798
protein kinase, interferon-inducible double stranded RNA dependent activator
IDBP-483631
protein kinase, interferon-inducible double stranded RNA dependent activator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25784705
The G3BP1-CAPRIN1-PRKRA complex represents a new mode of PRKRA activation and links stress responses with innate immune activation through PRKRA without a requirement for foreign double-stranded RNA pattern recognition.
PMID 26608320
A defective interfering RNA isolated from the Hu-191 vaccine strain of measles virus is sensed by PRKRA and DDX58 to initiate an innate antiviral response.
PMID 26454002
DDX3X participates in antiviral innate immunity by controlling translation of PRKRA.
Entrez Gene
Summary This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:178431414-178451512
Strand Reverse strand
Band q31.2
Transcripts
ENST00000325748 ENSP00000318176
ENST00000432031 ENSP00000393883
ENST00000424699 ENSP00000408029
ENST00000448279 ENSP00000388455
ENST00000457633 ENSP00000408668
ENST00000490501
ENST00000487082 ENSP00000430604
ENST00000474793
ENST00000470200
ENST00000460433
ENST00000466165
ENST00000463882
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
Experimentally validated
Total 73 [view]
Protein-Protein 69 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0016301 kinase activity
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0010467 gene expression
GO:0030422 production of siRNA involved in RNA interference
GO:0034599 cellular response to oxidative stress
GO:0042473 outer ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0043085 positive regulation of catalytic activity
GO:0045087 innate immune response (InnateDB)
GO:0048705 skeletal system morphogenesis
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002731
View Gene Order
ENSBTAG00000001096
Not yet available
Pathways
NETPATH
REACTOME
REACT_12417
MicroRNA (miRNA) biogenesis pathway
REACT_118560
Small interfering RNA (siRNA) biogenesis pathway
REACT_71
Gene Expression pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
ceramide_pathway
Ceramide signaling pathway
Cross-References
SwissProt O75569
TrEMBL B4DJC7 G5E9Q4
UniProt Splice Variant
Entrez Gene 8575
UniGene
RefSeq NM_003690 NM_001139517 NM_001139518
HUGO HGNC:9438
OMIM 603424
CCDS CCDS2279 CCDS46460 CCDS46461
HPRD 04573
IMGT
EMBL AC009948 AF072860 AF083033 AK223107 AK290601 AK296019 AL136615 AL833867 AY251164 BC009470 BT007243 CH471058 CR533525
GenPept AAC25672 AAD33099 AAH09470 AAP20061 AAP35907 AAX88882 BAD96827 BAF83290 BAG58789 CAB66550 CAD38725 CAG38556 EAX11036 EAX11037
RNA Seq Atlas 8575

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca