Homo sapiens Protein: PRKRA
Summary
InnateDB Protein IDBP-483631.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKRA
Protein Name protein kinase, interferon-inducible double stranded RNA dependent activator
Synonyms DYT16; PACT; RAX;
Species Homo sapiens
Ensembl Protein ENSP00000430604
InnateDB Gene IDBG-76030 (PRKRA)
Protein Structure
UniProt Annotation
Function Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, perinuclear region. Cytoplasm.
Disease Associations Dystonia 16 (DYT16) [MIM:612067]: An early-onset dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT16 patients have progressive, generalized dystonia with axial muscle involvement, oro-mandibular (sardonic smile) and laryngeal dystonia and, in some cases, parkinsonian features. {ECO:0000269PubMed:18243799, ECO:0000269PubMed:18420150}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
Experimentally validated
Total 73 [view]
Protein-Protein 69 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0016301 kinase activity
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006955 immune response
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0010467 gene expression
GO:0030422 production of siRNA involved in RNA interference
GO:0043085 positive regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR014720 Double-stranded RNA-binding domain
PFAM PF00035
PRINTS
PIRSF
SMART SM00358
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75569
PhosphoSite PhosphoSite-O75569
TrEMBL B4DJC7
UniProt Splice Variant
Entrez Gene 8575
UniGene
RefSeq NP_001132990
HUGO HGNC:9438
OMIM 603424
CCDS CCDS46461
HPRD 04573
IMGT
EMBL AC009948 AF072860 AF083033 AK223107 AK290601 AK296019 AL136615 AL833867 AY251164 BC009470 BT007243 CH471058 CR533525
GenPept AAC25672 AAD33099 AAH09470 AAP20061 AAP35907 AAX88882 BAD96827 BAF83290 BAG58789 CAB66550 CAD38725 CAG38556 EAX11036