Version 5.4
Homo sapiens Gene: TYSND1
Summary
InnateDB Gene IDBG-77238.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TYSND1
Gene Name trypsin domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000156521
Encoded Proteins
IDBP-77240
trypsin domain containing 1
IDBP-77242
trypsin domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:70137981-70146676
Strand Reverse strand
Band q22.1
Transcripts
ENST00000335494 ENSP00000335673
ENST00000287078 ENSP00000287078
ENST00000494143
ENST00000479086
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
GO:0016485 protein processing
GO:0031998 regulation of fatty acid beta-oxidation
GO:0051260 protein homooligomerization
Cellular Component
GO:0005777 peroxisome
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020087
View Gene Order
ENSBTAG00000038845
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.533655 Hs.600473
RefSeq NM_001040273 NM_173555
HUGO
OMIM
CCDS CCDS31213 CCDS31214
HPRD 15593
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca