Version 5.4
Homo sapiens Protein: TYSND1
Summary
InnateDB Protein IDBP-77242.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TYSND1
Protein Name trypsin domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000287078
InnateDB Gene IDBG-77238 (TYSND1)
Protein Structure
UniProt Annotation
Function Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta- oxidation of fatty acids. {ECO:0000269PubMed:22002062}.
Subcellular Localization Peroxisome {ECO:0000269PubMed:22002062}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
GO:0016485 protein processing
GO:0031998 regulation of fatty acid beta-oxidation
GO:0051260 protein homooligomerization
Cellular Component
GO:0005777 peroxisome
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR017345 Peptidase S1A, Tysnd1
PFAM PF00089
PRINTS
PIRSF PIRSF037989
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2T9J0
PhosphoSite PhosphoSite-Q2T9J0
TrEMBL
UniProt Splice Variant
Entrez Gene 219743
UniGene Hs.600473
RefSeq NP_775826
HUGO HGNC:28531
OMIM 611017
CCDS CCDS31213
HPRD 15593
IMGT
EMBL AL731540 BC016840 BC030242 BC111501
GenPept AAH16840 AAH30242 AAI11502 CAI13685 CAI13686

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca