Version 5.4
| Homo sapiens Gene: TANK | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-73552.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | TANK | ||||||||||||||||||||||
| Gene Name | TRAF family member-associated NFKB activator | ||||||||||||||||||||||
| Synonyms | I-TRAF; ITRAF; TRAF2 | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Ensembl Gene | ENSG00000136560 | ||||||||||||||||||||||
| Encoded Proteins |
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
TRAF family member-associated NFKB activator
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
TANK is involved in interferon responses and is a negative regulator of pro-inflammatory cytokine production induced by TLR signalling.
TANK plays a key role in the cross-talk between the IKK-related and the canonical IKK kinases, a mechanism required to limit the strength of TLR-signalling and prevent autoimmunity. (Demonstrated in mice)
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Mus musculus] Tank plays a key role in the cross-talk between the IKK-related and the canonical IKK kinases, a mechanism required to limit the strength of TLR-signalling and prevent autoimmunity.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 2:161136908-161236221 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | q24.2 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH |
TNFalpha pathway
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| REACTOME |
TRAF6 mediated IRF7 activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
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| KEGG |
RIG-I-like receptor signaling pathway pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | E7EVA2 E7EWR8 Q53TI5 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 10010 | ||||||||||||||||||||||
| UniGene | Hs.132257 Hs.715913 | ||||||||||||||||||||||
| RefSeq | NM_001199135 NM_004180 NM_133484 XM_005246206 XM_005246207 XM_005246208 XM_005246210 XM_005246211 | ||||||||||||||||||||||
| HUGO | HGNC:11562 | ||||||||||||||||||||||
| OMIM | 603893 | ||||||||||||||||||||||
| CCDS | CCDS2215 CCDS46436 | ||||||||||||||||||||||
| HPRD | 04870 | ||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | AC009299 AC009313 | ||||||||||||||||||||||
| GenPept | AAY14785 | ||||||||||||||||||||||
| RNA Seq Atlas | 10010 | ||||||||||||||||||||||