InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALDH1A2

Summary

InnateDB Protein

IDBP-13984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH1A2

Protein Name

aldehyde dehydrogenase 1 family, member A2

Synonyms

RALDH(II); RALDH2; RALDH2-T;

Species

Homo sapiens

Ensembl Protein

ENSP00000249750

InnateDB Gene

IDBG-13982 (ALDH1A2)

Protein Structure

UniProt Annotation

Function

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001758	retinal dehydrogenase activity
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016918	retinal binding

Biological Process

GO:0001568	blood vessel development
GO:0001822	kidney development
GO:0001889	liver development
GO:0001936	regulation of endothelial cell proliferation
GO:0002138	retinoic acid biosynthetic process
GO:0003007	heart morphogenesis
GO:0006776	vitamin A metabolic process
GO:0007494	midgut development
GO:0008152	metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009855	determination of bilateral symmetry
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0010628	positive regulation of gene expression
GO:0014032	neural crest cell development
GO:0016331	morphogenesis of embryonic epithelium
GO:0021915	neural tube development
GO:0021983	pituitary gland development
GO:0030182	neuron differentiation
GO:0030324	lung development
GO:0030326	embryonic limb morphogenesis
GO:0030900	forebrain development
GO:0030902	hindbrain development
GO:0031016	pancreas development
GO:0031076	embryonic camera-type eye development
GO:0032355	response to estradiol
GO:0033189	response to vitamin A
GO:0034097	response to cytokine
GO:0035115	embryonic forelimb morphogenesis
GO:0035799	ureter maturation
GO:0042572	retinol metabolic process
GO:0042573	retinoic acid metabolic process
GO:0042574	retinal metabolic process
GO:0042904	9-cis-retinoic acid biosynthetic process
GO:0043010	camera-type eye development
GO:0043065	positive regulation of apoptotic process
GO:0048384	retinoic acid receptor signaling pathway
GO:0048566	embryonic digestive tract development
GO:0048738	cardiac muscle tissue development
GO:0055114	oxidation-reduction process
GO:0060324	face development
GO:0071300	cellular response to retinoic acid