Version 5.4
Homo sapiens Gene: ALDH1A2
Summary
InnateDB Gene IDBG-13982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH1A2
Gene Name aldehyde dehydrogenase 1 family, member A2
Synonyms RALDH(II); RALDH2; RALDH2-T
Species Homo sapiens
Ensembl Gene ENSG00000128918
Encoded Proteins
IDBP-13984
aldehyde dehydrogenase 1 family, member A2
IDBP-13986
aldehyde dehydrogenase 1 family, member A2
IDBP-373822
aldehyde dehydrogenase 1 family, member A2
IDBP-590786
aldehyde dehydrogenase 1 family, member A2
IDBP-587546
aldehyde dehydrogenase 1 family, member A2
IDBP-591391
aldehyde dehydrogenase 1 family, member A2
IDBP-602138
aldehyde dehydrogenase 1 family, member A2
IDBP-592562
aldehyde dehydrogenase 1 family, member A2
IDBP-593547
aldehyde dehydrogenase 1 family, member A2
IDBP-594192
aldehyde dehydrogenase 1 family, member A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:57953424-58497866
Strand Reverse strand
Band q21.3
Transcripts
ENST00000249750 ENSP00000249750
ENST00000347587 ENSP00000309623
ENST00000430119 ENSP00000416754
ENST00000558384 ENSP00000453734
ENST00000560312
ENST00000558231 ENSP00000453600
ENST00000559517 ENSP00000453408
ENST00000560923
ENST00000559266
ENST00000561070 ENSP00000452850
ENST00000558595
ENST00000558239 ENSP00000453292
ENST00000557967 ENSP00000454028
ENST00000558073
ENST00000559297
ENST00000560122
ENST00000560863
ENST00000558504
ENST00000559579
ENST00000559625
ENST00000558524
ENST00000558946
ENST00000558603
ENST00000561098
ENST00000537372 ENSP00000438296
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001758 retinal dehydrogenase activity
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016918 retinal binding
Biological Process
GO:0001568 blood vessel development
GO:0001822 kidney development
GO:0001889 liver development
GO:0001936 regulation of endothelial cell proliferation
GO:0002138 retinoic acid biosynthetic process
GO:0003007 heart morphogenesis
GO:0006776 vitamin A metabolic process
GO:0007494 midgut development
GO:0008152 metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009855 determination of bilateral symmetry
GO:0009952 anterior/posterior pattern specification
GO:0009954 proximal/distal pattern formation
GO:0010628 positive regulation of gene expression
GO:0014032 neural crest cell development
GO:0016331 morphogenesis of embryonic epithelium
GO:0021915 neural tube development
GO:0021983 pituitary gland development
GO:0030182 neuron differentiation
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0031016 pancreas development
GO:0031076 embryonic camera-type eye development
GO:0032355 response to estradiol
GO:0033189 response to vitamin A
GO:0034097 response to cytokine
GO:0035115 embryonic forelimb morphogenesis
GO:0035799 ureter maturation
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
GO:0042574 retinal metabolic process
GO:0042904 9-cis-retinoic acid biosynthetic process
GO:0043010 camera-type eye development
GO:0043065 positive regulation of apoptotic process
GO:0048384 retinoic acid receptor signaling pathway
GO:0048566 embryonic digestive tract development
GO:0048738 cardiac muscle tissue development
GO:0055114 oxidation-reduction process
GO:0060324 face development
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013584
View Gene Order
ENSBTAG00000010119
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00830
Retinol metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Propanoate metabolism pathway
INOH website
Pyruvate metabolism pathway
INOH website
Valine Leucine Isoleucine degradation pathway
INOH website
Lysine degradation pathway
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.643455 Hs.692956 Hs.716113
RefSeq NM_001206897 NM_003888 NM_170696 NM_170697
HUGO
OMIM
CCDS CCDS10163 CCDS10164 CCDS45266 CCDS55968
HPRD 04733
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca