Version 5.4
Mus musculus Protein: Myzap
Summary
InnateDB Protein IDBP-182967.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myzap
Protein Name GRINL1A complex locus
Synonyms AA407270; AV006038; Gcom1; Gm640; Grinl1a7; Myozap;
Species Mus musculus
Ensembl Protein ENSMUSP00000091342
InnateDB Gene IDBG-182965 (Myzap)
Protein Structure
UniProt Annotation
Function Plays a role in cellular signaling via Rho-related GTP- binding proteins and activation of transcription factor SRF. Targets TJP1 to cell junctions (By similarity). In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:20093627}. Cell membrane {ECO:0000269PubMed:20093627}; Peripheral membrane protein {ECO:0000269PubMed:20093627}; Cytoplasmic side {ECO:0000269PubMed:20093627}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000269PubMed:20093627}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269PubMed:20093627}. Cell junction {ECO:0000250}. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin.
Disease Associations
Tissue Specificity Detected in heart myocardium and lung. {ECO:0000269PubMed:20093627}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0030018 Z disc
GO:0030054 cell junction
GO:0030864 cortical actin cytoskeleton
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031674 I band
Protein Structure and Domains
PDB ID MGI:2142908
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UIJ9
PhosphoSite PhosphoSite-Q3UIJ9
TrEMBL
UniProt Splice Variant
Entrez Gene 102371
UniGene Mm.27585
RefSeq NP_001028380
MGI ID
MGI Symbol Myzap
OMIM
CCDS CCDS23327
HPRD
IMGT
EMBL AK146889 BC139077 BC139078 CH466522
GenPept AAI39078 AAI39079 BAE27507 EDL26227

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca