InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tlr9

Summary

InnateDB Protein

IDBP-195820.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlr9

Protein Name

toll-like receptor 9

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082207

InnateDB Gene

IDBG-195818 (Tlr9)

Protein Structure

UniProt Annotation

Function

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection. {ECO:0000269PubMed:14993594, ECO:0000269PubMed:17474149}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:18305481}; Single-pass type I membrane protein {ECO:0000269PubMed:18305481}. Endosome {ECO:0000269PubMed:18305481}. Lysosome {ECO:0000269PubMed:18305481}. Cytoplasmic vesicle, phagosome {ECO:0000269PubMed:18305481}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.

Disease Associations

Tissue Specificity

Expressed in the basolateral region of gastric epithelial cells with high levels detected in antrum and body mucosa (at protein level). Detected in spleen and stomach at higher levels in C57BL/6 mice than BALB/C. {ECO:0000269PubMed:17474149}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	10 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0035197	siRNA binding
GO:0045322	unmethylated CpG binding

Biological Process

GO:0001774	microglial cell activation
GO:0002224	toll-like receptor signaling pathway
GO:0002237	response to molecule of bacterial origin
GO:0002282	microglial cell activation involved in immune response
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0008584	male gonad development
GO:0009615	response to virus
GO:0010508	positive regulation of autophagy
GO:0030277	maintenance of gastrointestinal epithelium
GO:0032715	negative regulation of interleukin-6 production
GO:0032728	positive regulation of interferon-beta production
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032741	positive regulation of interleukin-18 production
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034162	toll-like receptor 9 signaling pathway
GO:0042742	defense response to bacterium
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045356	positive regulation of interferon-alpha biosynthetic process
GO:0045359	positive regulation of interferon-beta biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050707	regulation of cytokine secretion
GO:0050727	regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0051607	defense response to virus
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0052033	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
GO:0071222	cellular response to lipopolysaccharide
GO:0071248	cellular response to metal ion

Cellular Component

GO:0005764	lysosome
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0032009	early phagosome