InnateDB Protein
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IDBP-227389.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KAZN
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Protein Name
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kazrin, periplakin interacting protein
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Synonyms
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KAZ;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000383601
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InnateDB Gene
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IDBG-90646 (KAZN)
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Protein Structure
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Function |
Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269PubMed:15337775}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}.Isoform 2: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.Isoform 3: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.Isoform 4: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.
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Disease Associations |
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Tissue Specificity |
Isoform 2, isoform 3 and isoform 4 are expressed in several cell lines including keratinocytes and bladder and epidermoid carcinoma (at protein level). Isoform 2, isoform 3 and isoform 4 are expressed in hair follicle and interfollicular epidermis (at protein level). {ECO:0000269PubMed:15337775}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q674X7
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PhosphoSite |
PhosphoSite-Q674X7
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TrEMBL |
B0QYQ6
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UniProt Splice Variant |
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Entrez Gene |
23254
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UniGene |
Hs.666837
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RefSeq |
NP_001017999
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HUGO |
HGNC:29173
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OMIM |
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CCDS |
CCDS41268
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HPRD |
11122
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IMGT |
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EMBL |
AB015329
AB028949
AK125794
AL031293
AL031732
AL034395
AL035405
AL391215
AL445263
AY505119
AY505120
AY505121
AY505122
BC035501
BC036877
BC101637
BC113621
CH471167
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GenPept |
AAH35501
AAH36877
AAI01638
AAI13622
AAS86434
AAS86435
AAS86436
AAS86437
BAA82978
BAA88115
BAC86294
CAI13899
CAI19827
CAQ06787
CAQ07837
CAQ08073
EAW51704
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