Version 5.4
Homo sapiens Gene: KAZN
Summary
InnateDB Gene IDBG-90646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KAZN
Gene Name kazrin, periplakin interacting protein
Synonyms KAZ
Species Homo sapiens
Ensembl Gene ENSG00000189337
Encoded Proteins
IDBP-90648
kazrin, periplakin interacting protein
IDBP-90650
kazrin, periplakin interacting protein
IDBP-90652
kazrin, periplakin interacting protein
IDBP-227387
kazrin, periplakin interacting protein
IDBP-227389
kazrin, periplakin interacting protein
IDBP-484790
kazrin, periplakin interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:14598704-15118043
Strand Forward strand
Band p36.21
Transcripts
ENST00000376030 ENSP00000365198
ENST00000376028 ENSP00000365196
ENST00000361144 ENSP00000354727
ENST00000400798 ENSP00000383602
ENST00000400797 ENSP00000383601
ENST00000491547
ENST00000503743 ENSP00000426015
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0031424 keratinization
Cellular Component
GO:0001533 cornified envelope
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030057 desmosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040606
View Gene Order
ENSBTAG00000015606
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368823 Hs.644194 Hs.666837
RefSeq NM_001017999 NM_001018000 NM_001018001 NM_015209 NM_201628 XM_005245795
HUGO
OMIM
CCDS CCDS152 CCDS30604 CCDS41267 CCDS41268
HPRD 11122
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca