InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KAZN

Summary

InnateDB Protein

IDBP-90648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KAZN

Protein Name

kazrin, periplakin interacting protein

Synonyms

KAZ;

Species

Homo sapiens

Ensembl Protein

ENSP00000365198

InnateDB Gene

IDBG-90646 (KAZN)

Protein Structure

UniProt Annotation

Function

Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269PubMed:15337775}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.Isoform 2: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.Isoform 3: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.Isoform 4: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.

Disease Associations

Tissue Specificity

Isoform 2, isoform 3 and isoform 4 are expressed in several cell lines including keratinocytes and bladder and epidermoid carcinoma (at protein level). Isoform 2, isoform 3 and isoform 4 are expressed in hair follicle and interfollicular epidermis (at protein level). {ECO:0000269PubMed:15337775}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0031424

keratinization

Cellular Component

GO:0001533	cornified envelope
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030057	desmosome

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q674X7