Version 5.4
Homo sapiens Protein: KAZN
Summary
InnateDB Protein IDBP-90652.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KAZN
Protein Name kazrin, periplakin interacting protein
Synonyms KAZ;
Species Homo sapiens
Ensembl Protein ENSP00000354727
InnateDB Gene IDBG-90646 (KAZN)
Protein Structure
UniProt Annotation
Function Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269PubMed:15337775}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}.Isoform 2: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.Isoform 3: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.Isoform 4: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.
Disease Associations
Tissue Specificity Isoform 2, isoform 3 and isoform 4 are expressed in several cell lines including keratinocytes and bladder and epidermoid carcinoma (at protein level). Isoform 2, isoform 3 and isoform 4 are expressed in hair follicle and interfollicular epidermis (at protein level). {ECO:0000269PubMed:15337775}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0031424 keratinization
Cellular Component
GO:0001533 cornified envelope
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030057 desmosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q674X7
PhosphoSite PhosphoSite-Q674X7
TrEMBL B0QYQ6
UniProt Splice Variant
Entrez Gene 23254
UniGene Hs.666837
RefSeq NP_001018000
HUGO HGNC:29173
OMIM
CCDS CCDS30604
HPRD 11122
IMGT
EMBL AB015329 AB028949 AK125794 AL031293 AL031732 AL034395 AL035405 AL391215 AL445263 AY505119 AY505120 AY505121 AY505122 BC035501 BC036877 BC101637 BC113621 CH471167
GenPept AAH35501 AAH36877 AAI01638 AAI13622 AAS86434 AAS86435 AAS86436 AAS86437 BAA82978 BAA88115 BAC86294 CAI13899 CAI19827 CAQ06787 CAQ07837 CAQ08073 EAW51704

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca