InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP19

Summary

InnateDB Protein

IDBP-231876.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP19

Protein Name

ubiquitin specific peptidase 19

Synonyms

ZMYND9;

Species

Homo sapiens

Ensembl Protein

ENSP00000381863

InnateDB Gene

IDBG-34363 (USP19)

Protein Structure

UniProt Annotation

Function

Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains. {ECO:0000269PubMed:19465887, ECO:0000269PubMed:21849505, ECO:0000269PubMed:22128162, ECO:0000269PubMed:22689415}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:19465887}; Single-pass membrane protein {ECO:0000269PubMed:19465887}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	75 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0014732	skeletal muscle atrophy
GO:0016579	protein deubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0031647	regulation of protein stability
GO:0034976	response to endoplasmic reticulum stress
GO:0048642	negative regulation of skeletal muscle tissue development
GO:0090068	positive regulation of cell cycle process
GO:1900037	regulation of cellular response to hypoxia

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR002893 Zinc finger, MYND-type
IPR007052 CS domain
IPR008978 HSP20-like chaperone
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443
PF01753
PF04969

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O94966

PhosphoSite