Homo sapiens Protein: DENND5B
Summary
InnateDB Protein IDBP-26016.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND5B
Protein Name DENN/MADD domain containing 5B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000346238
InnateDB Gene IDBG-26012 (DENND5B)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269PubMed:20937701}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001194 DENN domain
IPR005112 dDENN domain
IPR005113 uDENN domain
PFAM PF02141
PF03455
PF03456
PRINTS
PIRSF
SMART SM00799
SM00801
SM00800
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZUT9
PhosphoSite PhosphoSite-Q6ZUT9
TrEMBL
UniProt Splice Variant
Entrez Gene 160518
UniGene Hs.630714
RefSeq XP_005253383
HUGO HGNC:28338
OMIM
CCDS
HPRD 11321
IMGT
EMBL AB209341 AC022080 AC068792 AK095598 AK125323 BC020855 BC068580 BX537924 CH471116 CR749639
GenPept AAH20855 AAH68580 BAC04583 BAC86129 BAD92578 CAD97905 CAH18433 EAW88553