Homo sapiens Protein: DENND5B
Summary
InnateDB Protein IDBP-26018.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND5B
Protein Name DENN/MADD domain containing 5B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000373734
InnateDB Gene IDBG-26012 (DENND5B)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269PubMed:20937701}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001024 PLAT/LH2 domain
IPR001194 DENN domain
IPR004012 RUN
IPR005112 dDENN domain
IPR005113 uDENN domain
IPR008976 Lipase/lipooxygenase, PLAT/LH2
PFAM PF01477
PF02141
PF02759
PF03455
PF03456
PRINTS
PIRSF
SMART SM00308
SM00799
SM00593
SM00801
SM00800
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZUT9
PhosphoSite PhosphoSite-Q6ZUT9
TrEMBL
UniProt Splice Variant
Entrez Gene 160518
UniGene Hs.630714
RefSeq NP_659410
HUGO HGNC:28338
OMIM
CCDS CCDS44857
HPRD 11321
IMGT
EMBL AB209341 AC022080 AC068792 AK095598 AK125323 BC020855 BC068580 BX537924 CH471116 CR749639
GenPept AAH20855 AAH68580 BAC04583 BAC86129 BAD92578 CAD97905 CAH18433 EAW88553