Version 5.4
Mus musculus Protein: Bcl11a
Summary
InnateDB Protein IDBP-262226.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcl11a
Protein Name B-cell CLL/lymphoma 11A (zinc finger protein)
Synonyms 2810047E18Rik; BCL-11A; Ctip1; D930021L15Rik; Evi9; Evi9a; Evi9b; Evi9c; mKIAA1809;
Species Mus musculus
Ensembl Protein ENSMUSP00000105142
InnateDB Gene IDBG-155906 (Bcl11a)
Protein Structure
UniProt Annotation
Function Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. {ECO:0000269PubMed:12717432}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18681895}. Nucleus {ECO:0000269PubMed:18681895}. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles.
Disease Associations
Tissue Specificity Isoforms are expressed in a tissue-specific fashion. Isoforms 1, isoform 2, and isoform 3 are expressed at similar levels in testis, kidney and spleen. Isoform 1 is expressed in the stomach, and isoform 2 is expressed exclusively in the lung. Overexpression following proviral integration in hematopoietic cells results in the generation of myeloid leukemia.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010629 negative regulation of gene expression
GO:0016925 protein sumoylation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016604 nuclear body
Protein Structure and Domains
PDB ID MGI:106190
InterPro IPR007087 Zinc finger, C2H2
PFAM PF00096
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QYE3
PhosphoSite PhosphoSite-Q9QYE3
TrEMBL
UniProt Splice Variant
Entrez Gene 14025
UniGene Mm.53687
RefSeq NP_001152761
MGI ID
MGI Symbol Bcl11a
OMIM
CCDS CCDS48758
HPRD
IMGT
EMBL AF051525 AF169036 AF169037 AF186018 AK004395 AK043677 AK045556 AK049700 AK122557 BC010585 BC051418
GenPept AAF22430 AAF63682 AAF65928 AAF65929 AAH10585 AAH51418 BAB23285 BAC31616 BAC32416 BAC33881 BAC65839

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca