InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bcl11a

Summary

InnateDB Gene

IDBG-155906.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcl11a

Gene Name

B cell CLL/lymphoma 11A (zinc finger protein)

Synonyms

2810047E18Rik; BCL-11A; Ctip1; D930021L15Rik; Evi9; Evi9a; Evi9b; Evi9c; mKIAA1809

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000861

Encoded Proteins

IDBP-155908

B-cell CLL/lymphoma 11A (zinc finger protein)

IDBP-262226

B-cell CLL/lymphoma 11A (zinc finger protein)

IDBP-262228

B-cell CLL/lymphoma 11A (zinc finger protein)

IDBP-400992

B-cell CLL/lymphoma 11A (zinc finger protein)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119866:
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:24078056-24174123

Strand

Forward strand

Band

A3.2

Transcripts

ENSMUST00000000881	ENSMUSP00000000881
ENSMUST00000109516	ENSMUSP00000105142
ENSMUST00000109514	ENSMUSP00000105140
ENSMUST00000118955	ENSMUSP00000112948
ENSMUST00000124148
ENSMUST00000127494

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003676	nucleic acid binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010629	negative regulation of gene expression
GO:0010976	positive regulation of neuron projection development
GO:0010977	negative regulation of neuron projection development
GO:0016925	protein sumoylation
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0048671	negative regulation of collateral sprouting
GO:0048672	positive regulation of collateral sprouting
GO:0050773	regulation of dendrite development
GO:2000171	negative regulation of dendrite development
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016604	nuclear body

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000119866

View Gene Order

Cross-References

SwissProt

TrEMBL

Q5STS9

UniProt Splice Variant

Entrez Gene

14025

UniGene

Mm.397888 Mm.470356 Mm.487449 Mm.53687

RefSeq

NM_001242934 XM_006514504 XM_006514505 XM_006514506 XM_006514507 NM_001159289 NM_001159290 NM_016707

OMIM

CCDS

CCDS56764 CCDS24483 CCDS48758 CCDS48759

HPRD

IMGT

MGI ID

MGI:106190

MGI Symbol

Bcl11a

EMBL

AL662810 AL672018

GenPept

RNA Seq Atlas

14025