InnateDB Protein
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IDBP-400992.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Bcl11a
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Protein Name
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B-cell CLL/lymphoma 11A (zinc finger protein)
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Synonyms
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2810047E18Rik; BCL-11A; Ctip1; D930021L15Rik; Evi9; Evi9a; Evi9b; Evi9c; mKIAA1809;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112948
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InnateDB Gene
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IDBG-155906 (Bcl11a)
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Protein Structure
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Function |
Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. {ECO:0000269PubMed:12717432}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:18681895}. Nucleus {ECO:0000269PubMed:18681895}. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles.
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Disease Associations |
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Tissue Specificity |
Isoforms are expressed in a tissue-specific fashion. Isoforms 1, isoform 2, and isoform 3 are expressed at similar levels in testis, kidney and spleen. Isoform 1 is expressed in the stomach, and isoform 2 is expressed exclusively in the lung. Overexpression following proviral integration in hematopoietic cells results in the generation of myeloid leukemia.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
17 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:106190
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InterPro |
IPR007087
Zinc finger, C2H2
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QYE3
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PhosphoSite |
PhosphoSite-Q9QYE3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
14025
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UniGene |
Mm.53687
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RefSeq |
NP_001152762
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MGI ID |
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MGI Symbol |
Bcl11a
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OMIM |
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CCDS |
CCDS48759
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HPRD |
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IMGT |
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EMBL |
AF051525
AF169036
AF169037
AF186018
AK004395
AK043677
AK045556
AK049700
AK122557
BC010585
BC051418
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GenPept |
AAF22430
AAF63682
AAF65928
AAF65929
AAH10585
AAH51418
BAB23285
BAC31616
BAC32416
BAC33881
BAC65839
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