InnateDB Protein
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IDBP-35633.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SYNPO2
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Protein Name
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synaptopodin 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000306015
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InnateDB Gene
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IDBG-35631 (SYNPO2)
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Protein Structure
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Function |
Has an actin-binding and actin-bundling activity. {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber- like pattern. partly overlapping with filamentous actin. {ECO:0000250, ECO:0000269PubMed:18371299}.
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Disease Associations |
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Tissue Specificity |
Skeletal muscle specific. {ECO:0000269PubMed:11297942}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001478
PDZ domain
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PFAM |
PF00595
PF13180
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PRINTS |
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PIRSF |
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SMART |
SM00228
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UMS6
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PhosphoSite |
PhosphoSite-Q9UMS6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
171024
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UniGene |
Hs.655519
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RefSeq |
NP_597734
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HUGO |
HGNC:17732
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OMIM |
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CCDS |
CCDS34054
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HPRD |
15456
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IMGT |
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EMBL |
AC096745
AC107048
AC108030
AF177291
AJ010482
AL832031
AL833294
BC150629
EU481975
KF147165
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GenPept |
AAD55264
AAI50630
ACC93875
AGS94404
CAB51856
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