InnateDB Protein
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IDBP-372262.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PHF21A
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Protein Name
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PHD finger protein 21A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000398824
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InnateDB Gene
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IDBG-41419 (PHF21A)
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Protein Structure
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Function |
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. {ECO:0000269PubMed:16140033}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain. Expressed at much lower level in other tissues. {ECO:0000269PubMed:12032298}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
24
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001965
Zinc finger, PHD-type
IPR011011
Zinc finger, FYVE/PHD-type
IPR019787
Zinc finger, PHD-finger
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PFAM |
PF00628
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PRINTS |
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PIRSF |
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SMART |
SM00249
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TIGRFAMs |
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Modification |
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SwissProt |
Q96BD5
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PhosphoSite |
PhosphoSite-Q96BD5
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TrEMBL |
E9PR02
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UniProt Splice Variant |
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Entrez Gene |
51317
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UniGene |
Hs.597222
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RefSeq |
NP_001095272
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HUGO |
HGNC:24156
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OMIM |
608325
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CCDS |
CCDS44578
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HPRD |
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IMGT |
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EMBL |
AB051483
AC024475
AC068385
AC129913
AF208848
AK021530
AK023258
AY090777
BC015714
BX648236
CH471064
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GenPept |
AAF64262
AAH15714
AAM09095
BAB13839
BAB14492
BAB21787
CAH10542
EAW68012
EAW68013
EAW68015
EAW68017
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