Version 5.4
Homo sapiens Gene: PHF21A
Summary
InnateDB Gene IDBG-41419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHF21A
Gene Name PHD finger protein 21A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135365
Encoded Proteins
IDBP-41421
PHD finger protein 21A
IDBP-372262
PHD finger protein 21A
IDBP-593872
PHD finger protein 21A
IDBP-602096
PHD finger protein 21A
IDBP-584196
PHD finger protein 21A
IDBP-600784
PHD finger protein 21A
IDBP-591501
PHD finger protein 21A
IDBP-600359
PHD finger protein 21A
IDBP-589444
PHD finger protein 21A
IDBP-584187
PHD finger protein 21A
IDBP-595293
PHD finger protein 21A
IDBP-592879
PHD finger protein 21A
IDBP-596465
PHD finger protein 21A
IDBP-591401
PHD finger protein 21A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:45929323-46121178
Strand Reverse strand
Band p11.2
Transcripts
ENST00000323180 ENSP00000323152
ENST00000418153 ENSP00000398824
ENST00000527401
ENST00000530587 ENSP00000435984
ENST00000525676 ENSP00000431964
ENST00000532028 ENSP00000431621
ENST00000534724
ENST00000527753
ENST00000534766
ENST00000532883 ENSP00000432094
ENST00000525679
ENST00000524497 ENSP00000431273
ENST00000531959 ENSP00000432916
ENST00000529734 ENSP00000436157
ENST00000529782 ENSP00000435121
ENST00000533757 ENSP00000432406
ENST00000525438 ENSP00000437110
ENST00000527782 ENSP00000434687
ENST00000532010 ENSP00000435645
ENST00000528893
ENST00000530312
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001967 suckling behavior
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007596 blood coagulation
GO:0016568 chromatin modification
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000058318
View Gene Order
ENSBTAG00000009611
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.502458 Hs.597222
RefSeq NM_001101802 NM_016621 XM_005252962 XM_005252963 XM_005252964 XM_005252965 XM_005252967
HUGO
OMIM
CCDS CCDS31474 CCDS44578
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca