InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHF21A

Summary

InnateDB Protein

IDBP-41421.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHF21A

Protein Name

PHD finger protein 21A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323152

InnateDB Gene

IDBG-41419 (PHF21A)

Protein Structure

UniProt Annotation

Function

Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. {ECO:0000269PubMed:16140033}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain. Expressed at much lower level in other tissues. {ECO:0000269PubMed:12032298}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007596	blood coagulation
GO:0016568	chromatin modification