Version 5.4
Homo sapiens Protein: SYNPO2
Summary
InnateDB Protein IDBP-376662.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYNPO2
Protein Name synaptopodin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000390965
InnateDB Gene IDBG-35631 (SYNPO2)
Protein Structure
UniProt Annotation
Function Has an actin-binding and actin-bundling activity. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber- like pattern. partly overlapping with filamentous actin. {ECO:0000250, ECO:0000269PubMed:18371299}.
Disease Associations
Tissue Specificity Skeletal muscle specific. {ECO:0000269PubMed:11297942}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0051371 muscle alpha-actinin binding
GO:0071889 14-3-3 protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0015629 actin cytoskeleton
GO:0030018 Z disc
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
PFAM PF00595
PF13180
PRINTS
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UMS6
PhosphoSite PhosphoSite-Q9UMS6
TrEMBL
UniProt Splice Variant
Entrez Gene 171024
UniGene Hs.655519
RefSeq NP_001122406
HUGO HGNC:17732
OMIM
CCDS CCDS47128
HPRD 15456
IMGT
EMBL AC096745 AC107048 AC108030 AF177291 AJ010482 AL832031 AL833294 BC150629 EU481975 KF147165
GenPept AAD55264 AAI50630 ACC93875 AGS94404 CAB51856

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca