Version 5.4
Bos taurus Protein: CASP4
Summary
InnateDB Protein IDBP-680346.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASP4
Protein Name Caspase-4Caspase-4 subunit 1Caspase-4 subunit 2
Synonyms CASP13;
Species Bos taurus
Ensembl Protein ENSBTAP00000027820
InnateDB Gene IDBG-628941 (CASP4)
Protein Structure
UniProt Annotation
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1 (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}. Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0035234 ectopic germ cell programmed cell death
GO:0042981 regulation of apoptotic process
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050727 regulation of inflammatory response
GO:0070269 pyroptosis
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0072557 IPAF inflammasome complex
GO:0072559 NLRP3 inflammasome complex
GO:0097169 AIM2 inflammasome complex
Protein Structure and Domains
PDB ID
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001315 CARD domain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
IPR017350 Caspase, interleukin-1 beta convertase-type
PFAM PF00619
PF00656
PRINTS PR00376
PIRSF PIRSF038001
SMART SM00114
SM00115
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9C1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 338039
UniGene Bt.16018
RefSeq NP_788811
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF078533 AF383946 AF383947 BC112708 BT020999
GenPept AAC28380 AAI12709 AAK77964 AAK77965 AAX09016

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca