Version 5.4
Bos taurus Protein: PFN1
Summary
InnateDB Protein IDBP-685997.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFN1
Protein Name Profilin-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006465
InnateDB Gene IDBG-634231 (PFN1)
Protein Structure
UniProt Annotation
Function Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0001843 neural tube closure
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0030036 actin cytoskeleton organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR005454 Profilin, chordates
IPR005455 Profilin
PFAM PF00235
PRINTS PR01639
PR00392
PR01640
PIRSF
SMART SM00392
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P02584
PhosphoSite PhosphoSite-P02584
TrEMBL
UniProt Splice Variant
Entrez Gene 513895
UniGene Bt.90902
RefSeq NP_001015592
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102240 BT021078
GenPept AAI02241 AAX09095

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca