Version 5.4
Bos taurus Protein: ITGB1
Summary
InnateDB Protein IDBP-689427.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGB1
Protein Name Integrin beta-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000052015
InnateDB Gene IDBG-637396 (ITGB1)
Protein Structure
UniProt Annotation
Function Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation (By similarity). Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity). {ECO:0000250}.Isoform 2: Isoform 2 displaces isoform 1 in striated muscles. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Recycling endosome {ECO:0000250}. Melanosome {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions to fibrillar adhesions in an ITGB1BP1-dependent manner (By similarity). Localized in trophoblast basement membrane and basolateral surfaces of uninucleate cells. {ECO:0000250, ECO:0000269PubMed:7545439}.Isoform 2: Cell membrane, sarcolemma {ECO:0000250}. Cell junction {ECO:0000250}. Note=In cardiac muscle, isoform 2 is found in costameres and intercalated disks. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 101 interaction(s) predicted by orthology.
Predicted by orthology
Total 101 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0003779 actin binding
GO:0004872 receptor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0043236 laminin binding
GO:0046872 metal ion binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0007155 cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007161 calcium-independent cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
GO:0008284 positive regulation of cell proliferation
GO:0008354 germ cell migration
GO:0009615 response to virus
GO:0016032 viral process
GO:0016477 cell migration
GO:0021943 formation of radial glial scaffolds
GO:0031175 neuron projection development
GO:0031589 cell-substrate adhesion
GO:0033631 cell-cell adhesion mediated by integrin
GO:0043065 positive regulation of apoptotic process
GO:0045214 sarcomere organization
GO:0045596 negative regulation of cell differentiation
GO:0048675 axon extension
GO:0048738 cardiac muscle tissue development
GO:0051726 regulation of cell cycle
GO:0055007 cardiac muscle cell differentiation
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030175 filopodium
GO:0031594 neuromuscular junction
GO:0032587 ruffle membrane
GO:0034677 integrin alpha7-beta1 complex
GO:0035748 myelin sheath abaxonal region
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042995 cell projection
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0045202 synapse
GO:0055037 recycling endosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR014836 Integrin beta subunit, cytoplasmic domain
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold
PFAM PF00092
PF00362
PF07965
PF07974
PF08725
PRINTS PR01186
PIRSF PIRSF002512
SMART SM00327
SM00187
SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P53712
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281876
UniGene Bt.9973
RefSeq XP_005214205
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF468058 BC114107 DQ871214 U10865
GenPept AAA80571 AAI14108 AAL78037 ABH07895

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca