Version 5.4
Bos taurus Protein: SPINK1
Summary
InnateDB Protein IDBP-698970.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPINK1
Protein Name Pancreatic secretory trypsin inhibitor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020673
InnateDB Gene IDBG-646189 (SPINK1)
Protein Structure
UniProt Annotation
Function This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0010466 negative regulation of peptidase activity
GO:0010751 negative regulation of nitric oxide mediated signal transduction
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0060046 regulation of acrosome reaction
GO:0090281 negative regulation of calcium ion import
GO:1900004 negative regulation of serine-type endopeptidase activity
GO:2001256 regulation of store-operated calcium entry
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001239 Proteinase inhibitor I1, Kazal metazoa
IPR002350 Kazal domain
PFAM PF00050
PF07648
PRINTS PR00290
PIRSF
SMART SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P00996
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 574092
UniGene Bt.9636
RefSeq NP_001020519
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY911325 BC102485
GenPept AAI02486 AAW82093

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca