InnateDB Protein
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IDBP-699685.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ENTPD5
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Protein Name
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Ectonucleoside triphosphate diphosphohydrolase 5
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000027098
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InnateDB Gene
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IDBG-646846 (ENTPD5)
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Protein Structure
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Function |
Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum {ECO:0000250}. Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000407
Nucleoside phosphatase GDA1/CD39
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PFAM |
PF01150
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
E1BPW0
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PhosphoSite |
PhosphoSite-
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TrEMBL |
G5E5P3
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UniProt Splice Variant |
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Entrez Gene |
533096
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UniGene |
Bt.14106
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RefSeq |
NP_001179681
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AAFC03056279
DAAA02029604
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GenPept |
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