Version 5.4
Homo sapiens Gene: RIMS1
Summary
InnateDB Gene IDBG-92166.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIMS1
Gene Name regulating synaptic membrane exocytosis 1
Synonyms CORD7; RAB3IP2; RIM; RIM1
Species Homo sapiens
Ensembl Gene ENSG00000079841
Encoded Proteins
IDBP-92168
regulating synaptic membrane exocytosis 1
IDBP-92172
regulating synaptic membrane exocytosis 1
IDBP-294174
regulating synaptic membrane exocytosis 1
IDBP-383150
regulating synaptic membrane exocytosis 1
IDBP-383152
regulating synaptic membrane exocytosis 1
IDBP-383155
regulating synaptic membrane exocytosis 1
IDBP-478245
regulating synaptic membrane exocytosis 1
IDBP-481533
regulating synaptic membrane exocytosis 1
IDBP-482843
regulating synaptic membrane exocytosis 1
IDBP-479648
regulating synaptic membrane exocytosis 1
IDBP-480223
regulating synaptic membrane exocytosis 1
IDBP-478223
regulating synaptic membrane exocytosis 1
IDBP-474424
regulating synaptic membrane exocytosis 1
IDBP-483214
regulating synaptic membrane exocytosis 1
IDBP-484188
regulating synaptic membrane exocytosis 1
IDBP-475933
regulating synaptic membrane exocytosis 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:71886703-72403143
Strand Forward strand
Band q13
Transcripts
ENST00000370420 ENSP00000359448
ENST00000370419
ENST00000264839 ENSP00000264839
ENST00000401910 ENSP00000385649
ENST00000453976 ENSP00000389503
ENST00000425662 ENSP00000411235
ENST00000431478
ENST00000414192 ENSP00000402273
ENST00000491071 ENSP00000430101
ENST00000517960 ENSP00000429959
ENST00000518273 ENSP00000430408
ENST00000520567 ENSP00000430502
ENST00000522291 ENSP00000430932
ENST00000521978 ENSP00000428417
ENST00000517433 ENSP00000430359
ENST00000523963 ENSP00000428328
ENST00000524197
ENST00000517827 ENSP00000428367
ENST00000522211 ENSP00000429338
ENST00000463023
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
GO:0044325 ion channel binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006461 protein complex assembly
GO:0006886 intracellular protein transport
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007601 visual perception
GO:0014047 glutamate secretion
GO:0016079 synaptic vesicle exocytosis
GO:0017156 calcium ion-dependent exocytosis
GO:0042391 regulation of membrane potential
GO:0045055 regulated secretory pathway
GO:0046903 secretion
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048791 calcium ion-dependent exocytosis of neurotransmitter
GO:0050790 regulation of catalytic activity
GO:0050896 response to stimulus
GO:0061025 membrane fusion
Cellular Component
GO:0005886 plasma membrane
GO:0030054 cell junction
GO:0042734 presynaptic membrane
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041670
View Gene Order
ENSBTAG00000020238
Not yet available
Pathways
NETPATH
REACTOME
REACT_15293
Dopamine Neurotransmitter Release Cycle pathway
REACT_15309
Acetylcholine Neurotransmitter Release Cycle pathway
REACT_15425
Serotonin Neurotransmitter Release Cycle pathway
REACT_12591
Glutamate Neurotransmitter Release Cycle pathway
REACT_23947
GABA synthesis, release, reuptake and degradation pathway
REACT_15418
Norepinephrine Neurotransmitter Release Cycle pathway
REACT_13685
Neuronal System pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
KEGG
INOH
PID NCI
botulinumtoxinpathway
Effects of Botulinum toxin
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.485729 Hs.595825 Hs.606699 Hs.608538
RefSeq NM_001168407 NM_001168408 NM_001168409 NM_001168410 NM_001168411 NM_014989 XM_005248691 XM_006715388 XM_006715391 XM_006715392
HUGO
OMIM
CCDS CCDS47449 CCDS55029 CCDS55030 CCDS55031 CCDS55032 CCDS55033
HPRD 09435
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca